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S Fiorucci Selected Research

2- methyl- 3- (2- ((4- nitrooxybutyloxy)carbonyl)vinyl)phenyl ursodeoxycholic acid ester

5/2003Nitric oxide and portal hypertension: a nitric oxide-releasing derivative of ursodeoxycholic acid that selectively releases nitric oxide in the liver.
7/2001NCX-1000, a NO-releasing derivative of ursodeoxycholic acid, selectively delivers NO to the liver and protects against development of portal hypertension.
2/2001An NO derivative of ursodeoxycholic acid protects against Fas-mediated liver injury by inhibiting caspase activity.

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S Fiorucci Research Topics

Disease

11Inflammation (Inflammations)
08/2010 - 07/2000
2Insulin Resistance
02/2013 - 08/2011
2Duodenal Ulcer (Curling's Ulcer)
01/2011 - 12/2007
2Colitis
04/2007 - 11/2001
2Inflammatory Bowel Diseases (Inflammatory Bowel Disease)
04/2007 - 11/2001
2Portal Hypertension
05/2003 - 07/2001
2Rheumatoid Arthritis
09/2002 - 01/2000
2Ulcer
12/2001 - 12/2001
2Arthritis (Polyarthritis)
07/2000 - 01/2000
2Experimental Arthritis
07/2000 - 01/2000
2Hepatitis
02/2000 - 02/2000
1Dyslipidemias (Dyslipidemia)
02/2013
1Obesity
02/2013
1Cardiomyopathies (Cardiomyopathy)
02/2013
1Fibrosis (Cirrhosis)
02/2013
1Cardiotoxicity
02/2013
1Pruritus (Itching)
08/2011
1Liver Diseases (Liver Disease)
08/2011
1Fatty Liver
08/2011
1Alcoholic Fatty Liver
08/2011
1Non-alcoholic Fatty Liver Disease
08/2011
1Biliary Liver Cirrhosis (Primary Biliary Cirrhosis)
08/2011
1Hemorrhage
01/2011
1Myocardial Infarction
12/2007
1Stroke (Strokes)
12/2007
1Weight Loss (Weight Reduction)
04/2007
1Diarrhea
04/2007
1Hypotension (Low Blood Pressure)
05/2003
1Dyspepsia (Indigestion)
03/2002
1Bronchial Spasm
12/2001
1Liver Cirrhosis (Hepatic Cirrhosis)
07/2001
1Autoimmune Hepatitis
02/2001
1Neurodegenerative Diseases (Neurodegenerative Disease)
01/2001
1Peritonitis
12/2000
1Granuloma
12/2000
1Candidiasis (Moniliasis)
09/2000
1Reinfection
09/2000
1Infections
09/2000

Drug/Important Bio-Agent (IBA)

4LigandsIBA
02/2013 - 11/2001
32- methyl- 3- (2- ((4- nitrooxybutyloxy)carbonyl)vinyl)phenyl ursodeoxycholic acid esterIBA
05/2003 - 02/2001
3Nitric Oxide (Nitrogen Monoxide)FDA Link
05/2003 - 12/2000
3Ursodeoxycholic Acid (Urso)FDA LinkGeneric
05/2003 - 02/2001
3CytokinesIBA
09/2002 - 02/2000
3Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA
12/2001 - 01/2001
3CaspasesIBA
02/2001 - 08/2000
2Pharmaceutical PreparationsIBA
08/2011 - 05/2003
2AcidsIBA
08/2011 - 04/2007
2Naproxen (Naprosyn)FDA LinkGeneric
01/2011 - 07/2000
2ProstaglandinsIBA
12/2007 - 08/2000
2Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)IBA
12/2001 - 05/2001
2EnzymesIBA
12/2001 - 09/2000
2Concanavalin AIBA
02/2000 - 02/2000
1Triglycerides (Triacylglycerol)IBA
02/2013
1Insulin (Novolin)FDA Link
02/2013
1Fatty Acids (Saturated Fatty Acids)IBA
02/2013
1LipidsIBA
02/2013
1Glucose (Dextrose)FDA LinkGeneric
02/2013
1oxidized low density lipoproteinIBA
08/2011
1Alkaline PhosphataseIBA
08/2011
1rofecoxib (Vioxx)FDA Link
01/2011
1Salicylic Acid (2 Hydroxybenzoic Acid)FDA LinkGeneric
01/2011
1Biomarkers (Surrogate Marker)IBA
01/2011
1Antihypertensive Agents (Antihypertensives)IBA
01/2011
1Bile Acids and Salts (Bile Acids)IBA
08/2010
1Cyclooxygenase 2 Inhibitors (COX-2 Inhibitors)IBA
12/2007
1HydrogenIBA
04/2007
15-amino-2-hydroxybenzoic acid 4-(5-thioxo-5H-(1,2)dithiol-3yl)phenyl esterIBA
04/2007
1Mesalamine (Mesalazine)FDA LinkGeneric
04/2007
15- (4- hydroxyphenyl)- 3H- 1,2- dithiole- 3- thioneIBA
04/2007
1Peroxidase (Myeloperoxidase)IBA
04/2007
1Nitric Oxide DonorsIBA
05/2003
1levosulpirideIBA
03/2002
1Bronchoconstrictor AgentsIBA
12/2001
1Protein Isoforms (Isoforms)IBA
12/2001
1Analgesics (Analgesic Drugs)IBA
12/2001
1AntipyreticsIBA
12/2001
1PAR-2 ReceptorIBA
11/2001
1sym-trinitrobenzeneIBA
11/2001
1Peptides (Polypeptides)IBA
11/2001
1Sulfonic AcidsIBA
11/2001
1EstersIBA
02/2001
1Benzoic Acid (Potassium Benzoate)FDA Link
02/2001
1Flurbiprofen (Froben)FDA LinkGeneric
01/2001
1Thromboxane B2IBA
01/2001
1N- acetyl- S- (alpha- methyl- 4- (2- methylpropyl)benzeneacetyl)cysteine 4-(nitrooxy)butyl esterIBA
01/2001
1Dinoprostone (PGE2)FDA Link
01/2001
1Biological ProductsIBA
12/2000
1NitritesIBA
12/2000
1prednisolone 21-((4'-nitrooxymethyl)benzoate)IBA
12/2000
1ChemokinesIBA
12/2000
1Prednisolone (Predate)FDA LinkGeneric
12/2000
1SteroidsIBA
12/2000
1ZymosanIBA
12/2000
1Interferon-gamma (Interferon, gamma)IBA
09/2000
1Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
09/2000
1Interleukin-6 (Interleukin 6)IBA
09/2000
1Interleukin-12 (IL 12)IBA
09/2000
1Caspase 1 (ICE Protease)IBA
09/2000
1Interleukin-18 (Interleukin 18)IBA
09/2000

Therapy/Procedure

3Therapeutics
04/2007 - 07/2001